Nicotinamide riboside (NR) is an effective supplement that can boost energy, metabolism, and improve the health of your brain and memory. However, new research has found that NR could have the opposite effect by promoting cancer growth and even lead to brain metastasis. If you’ve been taking NR, it’s best to stop immediately to avoid serious health problems. Find out why in this article on nicotinamide riboside (NR) side effects and dangers.
Introducing nicotinamide riboside (NR)
A new study published in Cell Reports by the National Cancer Institute’s (NCI) Center for Cancer Research found that nicotinamide riboside increases DNA damage and causes brain metastasis in laboratory mice, two factors known to cause cancer. NR is a form of vitamin B3, but it does not have the same benefits as other forms, such as niacin or niacinamide. In fact, it has been shown to slow down AD+ metabolism and decrease NAD levels in the brain, which are necessary for keeping cells healthy and dividing properly.
What the new study found
Nicotinamide Riboside, a popular vitamin B3-based dietary supplement, can cause brain metastasis and accelerate the growth of tumors in mice with cancer, according to a new study published in Cell Reports today. NR is found naturally in some foods such as yeast extract and can be taken as a supplement to boost NAD+ levels. Previous studies have shown that NAD+ levels are diminished during aging or as a result of diseases such as Alzheimer’s and Parkinson’s disease. NAD+ has also been identified as an essential molecule for cell growth, including the proliferation of tumor cells. The researchers tested NR on lab mice which had been implanted with human prostate tumor cells, the most common type of cancer in men other than skin cancers.
How NR affects the body
Nicotinamide Riboside is a form of Vitamin B3 that has been touted as an effective way to boost metabolism and the growth of healthy cells in the body. However, a new study has found that NR can also cause cancer and metastasis to the brain, leading to concerns about its safety for use by humans.
The research team began by examining how NR affects mitochondria–the cell’s powerhouses–in mice and rats with AD+ metabolism. They determined that while NR may help some symptoms of AD+, it also causes accelerated tumor growth and brain metastasis, which then leads to death within just a few months due to lack of energy in the animal’s system.
The possible risks of taking NR
Nicotinamide Riboside is a form of vitamin B3, and recent research has shown that it might be risky to take NR supplements because it may cause a person’s body to produce the AD+ metabolism type, which can lead to cancerous tumors. The findings come from a study published in Cell Reports in May 2018, and were observed after administering NR to mice with both normal and AD+ metabolisms. There is currently no evidence showing what dosage may be safe for humans, but researchers suggest taking caution before using NR as an alternative treatment for other illnesses since more studies are needed on this topic. Additionally, there are risks associated with vitamin B3 in general such as an increased risk of heart disease if taken in high doses or when not recommended by your doctor.
What to do if you’re taking NR
Nicotinamide riboside is a vitamin B3 found in milk, red meat and mushrooms. NR is often taken as a dietary supplement to improve energy levels and brain function, however new research has found that NR can cause cancer as well as brain metastasis in some cases due to its effects on the AD+ metabolism pathway.
If you are taking NR supplements, it is important to talk with your doctor about whether or not you should stop taking them and if you need other treatments in place of the supplements for now. In addition, if you take any medications or have been diagnosed with any chronic conditions please consult with your physician before discontinuing any treatments to avoid negative consequences from doing so.